Mucoadhesive buccal patches of Aceclofenac were prepared using different polymers like hydroxypropyl methylcellulose, Carbopol 934-P, polyvinyl alcohol, polyvinyl pyrrolidone K-30, Eudragit L-100 in various proportion and combinations by solvent casting method. The prepared patches were smooth, elegant in appearance, uniform in thickness, mass and drug content. All the formulation showed folding endurance of 100. A 32 full factorial design was employed to study the effect of variable polymers like Carbopol 934-P and PVP K-30, hydroxypropyl methylcellulose, which significantly influenced characteristics like swelling index and ex vivo residence time of Aceclofenac buccal patches. In vitro drug release and in vitro drug permeation study showed that, from the formulation F10, the drug is released and permeated fastly. All the formulations are best fitted to Higuchi model.The stability study of selected patches were done in natural human saliva and it was found that all the patches were stable in human saliva
