Present study was designed to minimize the drug release in upper gastro intestinal tract and target to colon by using the principles of compression coat. Compression coated tablets are prepared by direct compression method using guar gum alone (or) combination of guargum/metalose 90 SH polymers. Tablets are evaluated for their physicochemical properties and in vitro drug release studies. All the properties of core and coat formulations are with in house specifications. In vitro drug release studies are performed without rat caecal contents (as a control) and with rat caecal contents. In the rat caecal contents formulations shows enhanced drug release due to degradation of guar gum coat by colonic galactomannanase enzyme. Coat thickness and amount of guargum/metalose 90 SH parameters controls the release rate. Compared to individual guar gum combination of guar gum with metalosee 90 SH (F9) provides minimize the drug release in upper GIT and maximizing the release of drug in colon. All the formulations ar best fitted with zero order kinetics and mechanism of drug release was non- Fickian (super case -II). FTIR studies reveals there is no drug-excipient interaction. Optimized F9 formulation was a promising system targeting to colon for treatment of various colonic diseases like Inflammatory Bowel disease (IBD).
