This present study an attempt was made to formulate beads of Metformin Hcl by using Sodium alginate in combination of HPMC , Carbopol ,Pectin and sodium caroxy methy cellulose. Beads of metformin Hcl were successfully prepared by Ionotropic Gelation Method .The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, loading capacity and in vitro release. The yields were varies from 78- 101.99% and encapsulation efficacy varie from 81.10 to 81.6 % which encourage the investigation depends upon the combination of sodium alginate with various polymers. The various parameters of model equation of beads containing Metformin Hcl in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.
