Fast dissolving tablets were highly accepted drug delivery system. Fast dissolving tablets were dissolved/disintegrated in the mouth within a matter of few seconds without need of water. The aim of the present study was to prepare and evaluate fast dissolving tablets of ketorolac tromethamine using a combined approach of subliming agent and superdisintegrant. Fast dissolving tablets were prepared by direct compression technique. The prepared tablets were dried under vacuum for camphor sublimation that results porous structure in the tablet. This porous structure results faster disintegration and drug release. The tablets were evaluated for weight variation, friability, hardness, In vitro disintegration time, wetting time, In vitro drug release profile. The porous structure of the tablet was observed under scanning electron microscopy (SEM).The obtained results showed that low weight variation, good hardness, acceptable friability. All the formulation disintegrated within 11-60 sec. The formulation containing subliming agent and superdisintegrants showed better performance in disintegration and drug release profile.
