The purpose of this research was to prepare and evaluate multiparticulate floating drug delivery system of aceclofenac. The microspheres were prepared by emulsification solvent evaporation technique using eudragit RS 100 as a release rate controlling polymer in the ratios 1:1, 1:2 and 1:3. The prepared microspheres were evaluated for drug-polymer compatibility, micromeritic properties, drug entrapment efficiency, in-vitro buoyancy and drug release studies. The mean particle size increased with increase in the polymer concentration, when compared to pure drug and it was lying between 14.71-25.93 μm. The micromeritic properties were found to be improved when compared to pure drug .Scanning electron microscopy confirmed the hollow structure with smooth external surface. The drug and polymer were found to be compatible as seen in IR studies. The entrapment efficiency considerably decreased with increase in the polymer concentration ranging from 78-36 % respectively. The microspheres floated up to 12 h over the surface of the gastric buffer medium and the buoyancy percentage was found to be in the range of 85-94%. In-vitro drug release studies showed that the prepared microspheres exhibited prolonged drug release for more than 12 hours. The mechanism of drug release was found to be a combination of both peppas and zero order release kinetics. The developed floating microspheres of aceclofenac may be used for prolonged drug release for at least 12 h for maximizing the therapeutic efficacy along with patient compliance.
