Introduction: Orodispersible tablets had received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry as oral drug delivery remains the preferred route for administration of various drugs. The purpose of the present research work was to formulate the orodispersible tablets of Hydralazine hydrochloride a drug of choice for eclampsia and pre-eclampsia to provide a suitable patient convenience dosage form an enhance to the bioavailability and to provide quick onset of action. Materials and Methods: Formulation of the orodispersible tablets of Hydralazine hydrochloride were prepared by using various superdisintegrants like crosspovidone, crosscarmellose sodium ,sodium starch glycolate by direct compression method. The formulas were evaluated for compatibility and Pre-Compression studies. The formulations were evaluated for weight variation, thickness, hardness, friability, content uniformity, disintegration time, wetting time, and water absorption ratio and release profile. Optimised formula was subjected to stability studies Results: Among all the formulations, F9 showed effective percentage of drug release at 12 minutes indicating faster and maximum absorption at the site of administration and showed superior quality based on stability reports.
