The present research work is based on the formulation of herbal effervescent granules by incorporating the crude extract of Limnophila indica for bacillary dysentery. The folklore of Andhra Pradesh widely use this plant for dysentery. The dried powder of the plant was extracted and then subjected to preliminary chemical tests. Then it was formulated into efferevescent granules and then evaluated for various parameters like angle of repose, dissolution studies, effervescent cessation time, stability studies, FTIR studies and invitro anti bacterial studies against three shigella species and invivo anti diarrheal studies by castor oil induced diarrhea. The preliminary chemical studies sthowe that the extract contains flavonoids, alkaloids and tannins. The formulated effervescent granules exhibited excellent flow properties which showed good angle of repose, carr’s index, Hausner’s ratio, bulk density and Tapped density. The dissolution profile was found to be very good. The FTIR studies showed that no drug polymer interactions were there. The accelerated stability studies revealed that the product will be stable for 57.9 months if stored at 27°C. The invitro antibacterial studies proved the formulation to possess more potent anti shigellosis activity than the standard ceftazidime used. The anti diarrheal activity exhibited the herbal effervescent granules to be more potent than the standard loperamide used.
