Der Pharmacia Lettre
Abstract
Author(s): B. Manjula, B. Mohammed Ishaq, C. Hari Kumar, G. Usha Rani
Ketoprofen is an anionic non-steroidal anti-inflammatory drug (NSAID), was selected as a
model drug. Different tablets formulations were prepared by wet granulation method. Required
quantity of drug, and low-density polymer (HPMC K4M, HPMC K100M and Ethyl cellulose),
alkalizing agent (sodium bicarbonate), and acidifying agent (citric acid) were passed through 60
mesh sieve and mixed thoroughly. Then, granulating agent (PVP) was added slowly with uniform
mixing the get a wet mass. The wet mass was passed through sieve no 16 to obtain wet granules.
The granules were dried at 50 Ã?â??Ã?º C for 5 to 6 hrs in tray dryer. The dried granules were passed
through sieve.no.22, after blending with lubricants (talc) was compressed using tablet
compression machine (11mm diameter punches). Each tablet contained 200mg of Ketoprofen
and other pharmaceutical ingredients. All the ten formulations were evaluated for various tests
like thickness, hardness, friability, weight variation, tablet density, swelling index, drug content,
dissolution, micromeritic properties and other kinetic parameters etc. Drug excipient
interactions were studied with IR technique which found that there was no interaction between
them. Total floating time and Buoyancy lag time were found to be satisfactory for 10th
formulation.
