The Flupirtine maleate matrix tablet were prepared using different hydrophilic polymers such as Sodium alginate ,Sodium Carboxy methylcellulose , Carbopol 934P in different proportions as release retarding agent to prolong the drug release and to improve the patience compliance. The prepared Flupirtine maleate matrix tablets were subjected to thickness, friability, weight variation, drug content uniformity, hardness, swelling index and in vitro drug release studies. The drug excipients compatability was estimated by FTIR and DSC studies. All the formulation showed compliance with pharmacopoeial standard. The In vitro dissolution study shows that F3 formulation was releases the drug in a controlled manner for 12 hours. Among all the formulations, formulation F3 which contains sodium alginate 20% releases the drugs which follow Zero order kinetics. The DSC and FTIR studies revealed that there was no interaction between Flupirtine maleate and excipients. Hence different hydrophilic polymers (sodium alginate, sodium carboxy methylcellulose carbopol 934 p) in various proportions can be used to prepare matrix tablets of Flupirtine maleate having prolonged therapeutic effect with enhanced patience compliance.
