Floating bilayer tablet of clopidogrel bisulfate contained two layers, one was immediate release and other was sustained release layer. First immediate release layer quickly released drug with attained quick onset of action and the other layer floated on gastric fluid and released the drug in sustained manner. The optimum batch F7 showed 19 hrs of floating time, 94.25 % of CDR up to 12 hrs. While for immediate release the optimized batch F2 showed 93.55 % of drug content, 92.25 % of CDR at 60 min. So, bilayer floating tablet of clopidogrel bisulfate with all desired attributes were prepared and evaluated. Bilayer floating tablet of clopidogrel bisulfate was prepared successfully by direct compression method. Pre-compression evaluations of powder blend of both layers were performed for tapped density, bulk density, Hauser ratio and Compressibility Index with all tests showed satisfactory results.
