The objective of this study was to formulate and evaluate Salbutamol sulphate matrix tablets, extended release dosage form, for the treatment of Chronic Obstructive Pulmonary Disease (COPD). The ER tablets were prepared by direct compression method using two polymers such as hydroxyl propyl methyl cellulose (HPMC K100M) and xanthan gum in varying ratios. Powder blends were evaluated for loose bulk density, tapped bulk density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability, and drug content. The results of all these tests were found to be satisfactory. The in vitro dissolution study was carried out for 24 hours using type II dissolution apparatus. Among all the formulation, F7 shows 96.49% of drug release at the end of 12 hours. This finding reveals that above a particular concentration of HPMC K-100M and xanthan gum are capable of providing extended drug release.
