The present study was undertaken with an aim to formulate doxycycline hydrochloride delayed release tablets. Successful delivery of drugs specifically to the intestine requires the protection of drug from being released in stomach. This drug is universal antibiotic and can be targeted to the specific site of absorption by enteric coating using pH dependant polymers. The present study demonstrates that the doxycycline hydrochloride compression coated tablets could be targeted to intestine using pH dependent polymers. Preformulation studies like angle of repose, bulk density, tapped density, porosity, Carr's index, Hausner's ratio were performed. Enteric coating was carried out using different polymers like Eudragit L-30 D-55, hydroxy propyl methylcellulose phthalate, cellulose acetate phthalate and acryl-EZE® to achieve 5% weight gain and 9 % weight gain. These batches were evaluated for hardness, friability, weight variation, drug content, disintegration and invitro dissolution
