The present study aimed to prepare and evaluate Diclofenac sodium transferosomes for transdermal drug delivery. Transferosomes were prepared by thin film hydration method by varying the ratios of soya lecithin and surfactants in the organic phase. Three surfactants i.e. Span 20, span 60, span 80 were selected for the present study. Drug concentration was kept constant. With each surfactant 5 formulations were prepared. The prepared formulations were evaluated for vesicle size, morphology, zeta potential, drug content, entrapment efficiency and invitro skin permeation. It was investigated that among three surfactants span 60 was considered to be a better surfactant because of its small vesicle diameter and high entrapment efficiency with good stability. By using span 60, 5 formulations were prepared by varying the concentration of soyalecithin to surfactant. Among the 5 formulations of span 60, F10 formulation with 2:1 ratio of soyalecithin to surfactant was found to have the highest entrapment efficiency of 62.2%, drug content of 96.5%, vesicle size of 257.1nm, zeta potential of -25mv. The drug release was continued upto 12 hrs and 58.9% of drug has been released from the formulation representing the sustained release nature when compared to span 20 and span 80. The present study revealed successful preparation of Diclofenac sodium transferosomes, effect of type of surfactant and soyalecithin:surfactant ratio on entrapment efficiency, vesicle morphology and drug release was studied.
