Mouth Fast Dissolving Tablets (MFDT’s) have emerged as an alternative to conventional oral dosage forms to improve the patient compliance. Due to problem in swallowing ability with age, the pediatric and geriatric patients complain of difficulty to take conventional solid dosage forms . The MFDT’s are solid dosage forms that dissolve or disintegrate rapidly in the oral cavity, which results in solution or suspension without the need of water. The main objective of this work is to formulate and evaluate Cetirizine HCl MFDT’s using different concentrations of superdisintegrants like croscarmellose sodium (CCS), crospovidone (CP), sodium starch glycolate (SSG). Tablets were prepared by direct compression method and evaluated for hardness, friability, wetting time, disintegration time and percent drug release. FT-IR studies revealed that there was no interaction between Cetirizine HCl and the excipients used in the study. The results indicate that formulation prepared with 5% croscarmellose sodium was found to be optimized which provides maximum drug release (99%) and minimum disintegration time (less than 20sec). Stability studies of optimized formulation revealed that formulation is stable.
