Caplet containing Aceclofenac- sustained release (SR) and Rabeprazole sodium – enteric coated (EC) tablets was developed. Aceclofenac is a non steroidal anti inflammatory drug (NSAIDS) having poor water solubility and short t1/2 of 4 hours hence formation of its solid dispersion further sustaining its release to give good dissolution after release for a specific period of time. Rabeprazole is an acid- labile, proton pump inhibitor thus enteric coated by using CAP to prevent its degradation in acidic environment and HPMC to sustain its release too.
