Der Pharmacia Lettre
Abstract
Author(s): Umesh. D. Shivhare, Parag. D. Bodkhe, Kishor P.Bhusari, Vijay B. Mathur
Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were
developed and characterized for improving bioavailability. The films were formulated by solvent
casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit
RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis
of their physical characteristics, bioadhesive performance and other parameters. In vitro studies
revealed that release rate of losartan potassium was higher from films containing ratio of HPMC
and Eudragit RL100 in proportion of 2:2. Drug diffusion from buccal films showed Peppas
model kinetics and release mechanism was non-fickian. All the films exhibited sufficient in vitro
bioadhesion strength. Promising formulation was further studied for temperature dependant
stability studies. The results indicated that, therapeutic level of losartan potassium can be
achieved using this buccoadhesive formulation.
