The aim of our research work was to formulate and evaluate sustained release tablets of atorvastatin using the biomaterial as a novel bio-binder for the formulation of tablets. The bio-material was isolated from the unripe fruit pulp of Artocarpus heterophyllus by simplified economic process. It was subjected for various physicochemical parameters like color, colour changing point, chemical tests, IR spectral study. Ibuprofen sustained release tablets were prepared by using various formulation additives. Three atorvastatin loaded formulations(FA1-FA3) were prepared by using varying polymer ratios of 1:1, 1:3, 1:5 and other excipients like starch, talc, lactose. The formulations were evaluated for hardness, friability, weight variation, disintegration and in-vitro release study. On the basis of evaluation parameters formulation FA3 was found to be the best as It showed a t50% of 400 mins and t80% of more than 10 hours with weight variation of 3.8%, friability of 1.2%, hardness of 5 kg/cm2and disintegration time of around 12 mins. A smart conclusion was drawn that the bio-material can serve as a potential agent for formulating various sustained release formulations for the treatment of various chronic ailments along with the advantages of being non-toxic, biodegradable and free from any adverse effects.
