Floating beads have been utilized to obtain prolonged and uniform release of drug in the stomach for development of once- daily formulation. The objective of this investigation was to develop intragastric floating drug delivery system of Triprolidine hydrochloride and also attempts were made to sustain the release of Triprolidine hydrochloride. Floating alginate beads of Triprolidine hydrochloride were prepared from sodium alginate solution containing gellan gum, methyl cellulose and corn oil by using ionotropic gelation method. These beads were evaluated for drug content, entrapment efficiency, floating duration, swelling index and in- vitro drug release. The floating time of beads was found excellent and they remain float for 12 hrs and also shows release characteristics for 12 hrs. Formulation F7 batch showed highest drug content, drug release and scanning electron microscopy revealed that the beads were spherical in shape with rough surface. The result demonstrated that oil entrapped gel beads can be used as floating drug delivery system for local as well as systemic drug delivery.
