In this investigation, development of oral fast dissolving tablet of Etoricoxib was developed to overcome solubility problem of Etoricoxib. Dissolution of Etorioxib enhanced by solid dispersion technique in which Etoricoxib-carrier Urea solid dispersion were prepared by physical mixture (PM), kneading (KN) and by fusion method (FM) techniques, in three molar rations (1:1, 1:2 and 1:3). In formulation Mannitol used to maintain rapid disintegration and Urea added which acts as hydrophilic carrier and superdisitigrant. Preparation of tablet by direct compression and evaluation were done. From dissolution study results, method of solid dispersion technique and drug- carrier ratio was optimized. Taste masking of bitter Etoricoxib was done by using Aspartame, In vitro and In vivo taste evaluation was done. Compatibility between drug and excipient examine by FTIR study.
