The aim of the present work was to prepare and evaluate mucoadhesive tablets of Rebapimide to prolong the gastric residence time after oral administration. The solubility of Rebapimide was enhanced by kneading technique with that mixture formulations were prepared by using 33 full factorial designs to explore the effects of Gum Kondagogu, Gum Olibanum and Guar Gum (as independent variables) on mucoadhesive strength, drug release and Ex vivo residence time (as dependent variables). The tablets were evaluated for various parameters such as compatibility studies, drug content, weight variation, hardness, thickness, friability, swelling studies, in vitro drug release studies, in vitro mucoadhesion strength , Ex vivo residence time test and release rate kinetics. The drug-polymer interaction was also studied by conducting FTIR. The in vitro release kinetics studies reveal that all formulations fits well with Zero order, followed by Korsmeyer-Peppas, Higuchi and the mechanism of drug release is erosion. After analysis of different evaluation parameters and drug release kinetics, formulation code F13 was selected as a promising formulation for delivery of Rebapimide as a mucoadhesive Gastroretentive tablet with best mucoadhesive strength and 99.34% drug release at 12th hour. The main effects and the interaction terms were quantitatively evaluated by quadratic model. The stability studies were carried out at 40°C/75% RH for 180 days. There was no significant change in the physical property and weight variation, hardness, thickness, friability, in vitro drug release studies, in vitro mucoadhesion strength, drug content during the study period.
