Der Pharmacia Lettre
Abstract
Author(s): Rakesh Pahwa, Neeta, Shiv Bhagwan, Vipin Kumar, Kanchan Kohli
Various scientific and technological attempts have been made in the development of
gastroretentive dosage forms to overcome several physiological adversities, such as short
gastric residence time, unpredictable gastric emptying time etc. These dosage forms can be
retained in the stomach for prolonged period of time in a predetermined manner.
Gastroretentive drug delivery technology is one of the promising approach for enhancing the
bioavailability and controlled delivery of drugs that exhibit narrow absorption window. In
pursuit of this endeavour, different novel strategies have been undertaken for the designing of
several gastroretentive drug delivery systems including floating microspheres. This
manuscript highlights various developmental approaches, characterization aspects, potential
drug candidates along with diverse advantages and applications of floating microspheres.
Numerous significant research findings in the vistas of these multiparticulates have also been
described.
