The study of cytotoxic effects of methanolic extract and their fractions of leaves Merremia peltata (L.) Merr., (Fam. Convolvulaceae) had been done by Brine Shrimp Lethality Method. Results showed that the methanolic extract have cytotoxic (LC50) 19.68 ppm, n-hexane fraction 22.03 ppm, ethyl acetate fraction 130.92 ppm, and methanolic fraction 532.11 ppm respectively, while the water residue fraction have no activity below 1.000 ppm.
