Phytochemical screening, antimicrobial and GC-MS analysis of the ethyl acetate and methanol crude extracts of the aerial parts of Palista hirsota and Raovofovia vomiti were studied in this work. The aim of the work is to ascertain the strength of the different solvent extracts of both plants in terms of microbial potency and chemical composition since both plants are used in Agbarho community for the treatment is bacteria and fungi infections. The preliminary screening of the various extracts was carried out using standard methods and the results revealed the presence of steroids and saponins for the ethyl acetate extract of Raovofovia vomiti while terpenes, steroids, flavonoids carbohydrate and saponins were present in the methanol extract of Palista hirsota. The antimicrobial screening was carried out on both plant extracts using the organisms; Salmonellae Typhi, Esherichia coli, Staphylococcus aureus, Klebsiella Pneumonia, Pseudomonas, Candida Krusei and Candida albican. The extract from Raovofovia vomiti produced a zone of inhibition of 20 mm, 10 mm and 10 mm for the organisms Salmonellae Typhi, Staphylococcus aureus, and Candida albican respectively with a corresponding MBC/MFC of 50mg/ml each while the extract from Palista hirsota has significant zone of inhibition on all the organisms tested against with a corresponding MBC/MFC >100mg/ml for organisms. The major compound detected by the library search of the data base in the GC-MS analysis revealed that both compound G1 and D1 from the aerial parts of the plants P. hirsota and R. vomitoria is octadecanoic acid also called stearic acid with the molecular formula C18H36O2, molecular weight 284g/mol and with a percent peak area of 45.58% for compound D1 from the aerial parts of R. vomitoria and 29.27% for Palista hirsota
