Der Pharmacia Lettre
Abstract
Author(s): A.Pandurangan , R.L Khosa and S.Hemalatha
The methanol extract of Ichnocarpus frutescens R. Br (Apocynaceae) roots were investigated for
the evaluation of their wound healing potential on different experimental models of wounds in
rats. The methanol extract of roots (MEIF), in the form of an ointment with two different
concentrations (1 % and 2 % w/w ointment of root extract in simple ointment base) was
evaluated for wound healing potential in an excision wound model and an incision wound model
in rats. Both concentrations of the methanol extract ointment showed significant responses in
both the wound types tested when compared with the control group. The effect produced by the
extract ointment, in terms of wound contracting ability, wound closure time, regeneration of
tissues at wound site, tensile strength of the wound and histopathological characteristics were
comparable to those of a standard drug framycetin sulphate cream.
