Der Pharmacia Lettre
Abstract
Author(s): Divya Raj, Sankar.C, Dilip.C, Azeem.A.K, Lisa Mary Mani, Lintu Mathew, Abdul Bari M Mambra, Senthil.V, Saranya.T.S, Suhail.K.C, Umapathi. S
The purpose of the study is to select a new cheap, effective alternative natural suspending agent
for pharmaceutical suspensions. Comparative study between the Leucaena Latisiliqua seed gum
and known gums like Tragacanth, Acacia were done. Leucaena Latisiliqua seed was boiled and
the seed gum was extracted with acetone, dried and powdered. Then its phytochemical
investigation, swelling index was determined. Different type of zinc oxide suspensions using
Leucaena Latisiliqua seed gum, Tragacanth, Acacia were prepared and effect of type and
concentration of suspending agent on sedimentation volume, viscosity and particle size were
studied. The phytochemical test showed the presence of less common sugar. The zinc oxide
suspension prepared in batches containing Leucaena gum, compound tragacanth, acacia and the
result showed that sedimentation volume, viscosity, and the particle size were found directly
proportional to the concentration of suspending agent and inversely proportional to the flow
rate. The suspending ability of the suspending agents were in the order of Leucaena Latisiliqua
gum > Compound Tragacanth >Acacia. From the results, it was concluded that the gum of
Leucaena Latisiliqua can be employed as stabilizer and thickener of choice when high viscosity
is desired.
