Nephroprotective activity of Aerva lanata whole plant extract in 5/6 nephrectomized rat model were carried out. Different parameters like post operative survival rate, change in body weight, levels of RBC, hemoglobin, triglyceride, cholesterol, creatinine, urea, uric acid, sodium and potassium were estimated in experimental rats. The findings revealed that post operative survival rate of rats in the investigated novel method to be 100%. Change in the body weight of ethanolic extract of Aerva lanata whole plant (EALE) treated groups-I and II was found to be 32gms and 30gms respectively. The above values suggested that EALE treatment normalized the elevated body weight level in experimental rats. Furthermore EALE treatment normalized the decreased RBC level and also normalized the elevated hemoglobin, triglyceride, cholesterol, creatinine, urea,uric acid, Sodium and Potassium levels in experimental rats. The results indicate that Aerva lanata has strong nephroprotective activity. But, further scrutiny is essential for isolation and characterization of the active components, which can be employed to allay various human maladies
