The aqueous extract of mangifera indica leaf was administered orally at a dose of 400mg/kg body weight to both normal and alloxan-induced diabetic rats. Twenty four (24) rats divided into 4 groups of 6 rats in each group of which two groups were made diabetic and the other two groups were normal. One of diabetic groups was treated with the extract and the second served as diabetic control. The alloxan was given through intraperitoneal route at a concentration of 150mg/kg body weight. The administration of the extract lasted for 21 days. Effect of the extract on glucose, cholesterol, triglycerides, High density lipoprotein and protein concentrations were analysed. The toxic effect of the extract was determined using biochemical enzyme markers. The phytochemical screening of the aqueous extract and ethanol extract showed the presences of flavonoids, tannins, cardiac glycosides, resins, sterols, balsam and saponins. Treatment of the diabetic rats with the aqueous extract showed significant (p<0.05) reduction in the levels of glucose, cholesterol, triglyceride and enzymes activities therefore Mangifera indica aqueous extract showed that it possesses hypoglycaemic and hypolipidaemic properties and showed no toxic effect on the liver at the concentration employed and may be used for the management of diabetes mellitus.
