A Polyherbal formulation, Livomyn comprising of phytoconstituents with potential hepatoprotective activity was evaluated for its hepatoprotective and antioxidant activity using Carbontetrachloride (CCl4) induced hepatotoxicity in Sprague Dawley rats. Livomyn is composed of the extracts of plants like Andrographis paniculata, Phyllanthus niruri,Triphala, Boerhaavia diffusa, Amoora rohituka, Chicorium intybus, Adhatoda vasica, Eclipta alba, Zingiber officinale,Berberisaristata,Fumariaofficinalis,Embelliaribes,Tephrosiapurpurea,TinosporacodifoliaCoriandrumsati vum,Aloebarbadensis,Picrorrhizakurroa.Hepatotoxicity was induced in Sprague Dawley rats by intraperitoneal injection of CCl4(1.5mL kg_1,60 in olive oil,1:1 ratio). Livomyn at a dose of 120, 240, 480 mg/kg/day and Silymarin standard 50mg/kg/day was administrated orally for 7 days.The Hepatoprotective effect of Livomyn and standard was evaluated by the assay of biochemical parameters viz…Serum Glutamate Pyruvate Transaminase (SGOT), Serum Glutamate Oxaloacetate Transaminase (SGOT), Alkaline phosphate (ALP), Total Bilirubin Protein (TBP), whereas DPPH Scavenged % was estimated to evaluate antioxidant activity. The toxic effects of CCl4 in Livomyn treated group was controlled significantly by restoration of the levels of serum bilirubin protein, enzymes as compared to the CCl4 treated and silymarin treated groups. Livomyn showed significant hepatoprotective activity as indicated by a decrease in serum marker enzymes (SGOT, SGPT and ALP and increase TBP in a dose dependant manner. Histopathological studies further confirmed the hepatoprotective activity of Livomyn. The present findings are indicative of the hepatoprotective effects of Livomyn against CCl4 induced oxidative damage being related to its antioxidant and free radical scavenging activity.
