With the advent of nanotechnology, new area has developed in the realm of textile finishing. These textiles can be widely used for hygienic clothing, wound healing, and medical applications in hospitals and other places where bacteria present a hazard .Enhancement of textile materials by nanotechnology is expected to become a trillion dollar industry in the next decade with tremendous technological, economic and ecologic benefits. In the present study, the effect of natural polymer gum acacia coated copper nanoparticles loaded levofloxacin drug nano conjugate fabricated wound dressing on the mechanical properties and antibacterial activity against pyogenic bacteria has been studied. Nano drug conjugate was prepared by one step reduction of metal precursor –polymerantibiotic suspension with sodium borohydride. Synthesized drug conjugate was characterized by UV Visible spectroscopy, fourier transform infrared (FTIR) spectroscopy and electron microscopy. Nano drug conjugate coating was carried out by pad dry cure method. Fabricated dressing materials were examined in the range of basic physical–mechanical parameters followed by its functional properties. Antibacterial activity was studied against pyogenic bacteria by solid plate assay. Effect of nano drug conjugate on the mechanical properties clearly revealed distinct changes in mechanical and anti bacterial properties Nano coating revealed increased air permeability and no effect on the bursting strength.Anti bacterial activity showed that both the tested bacterial strains were effectively inhibited by the nano drug conjugate coated wound dressing treatment. Further study will helpful to fabricate polymer coated drug conjugate on wound dressing to fight against pyogenic bacterial infection.
