Moleneria recurpata is an herb (also known as palm grass). This herb is available in the hilly areas of Tripura. The plant is well known for it’s different folk medicines like leaves are used in bone fracture, in wound healing and as analgesic, anthelmintic. It was observed that the people of Tripura especially Tribes are use the juice of matured leaf in worm. The economic importance of this plant is, fibers that are collected from this plant have been used for purposes such as making nets, and the fruit is edible. The present study was carried out to evaluate the anticoagulant activity of Molineria recurpata (Family: Hypoxidaceae) leaf extract (Methanol) on fresh human blood. Both the extracts were found sufficient anti-coagulant activity. But the concentration of 2g/ml methanolic leaf extract showed the maximum effect with respect to others. The isolation of active constituents those are responsible for different activities are going on in our laboratory.