The current study compares the two extraction method and evaluates the hepatoprotective and lipid peroxidation study of Crataeva magna Buch Ham (family Capparidaceae). The finding of the results reveals that the sequential extraction method was significantly reduced the serum level of liver enzyme asparate aminotransferase (AST), alanine aminotransferase (ALP) when compared with the maceration method which were assessed against carbon tetrachloride induced hepatotoxicity rats. Further the lipid peroxidation activity of the methanolic extract obtained from sequential method was analyzed, which show significant result with IC50 = 0.176 mg/ml. Hence the methanolic extract obtained from the sequential extraction process represents a source hepatoprotective effect, probably acting by promoting the antioxidant defense system.
