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Evaluation of dihydropyridine calcium antagonist effects on the stress bioindicator organism Saccharomyces cerevisiae | Abstract
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Abstract

Evaluation of dihydropyridine calcium antagonist effects on the stress bioindicator organism Saccharomyces cerevisiae

Author(s): Cherait Asma and Djebar Mohamed Reda

Nifedipine is the subject of several studies since their introduction into clinical medicine in 1975. Some of them found it as a protective solution against stress increase, but others works demonstrate that can be a stress source. That’s why in this present paper we want to put in evidence the effect which has this molecule on bioindicator stress: the yeast Saccharomyces cerevisiae. These effects have been studied by measuring the cell proliferation, respiratory activity and the levels of some biomarkers (CAT, MDA). The results obtained show a significant inhibition on cell proliferation of yeast and respiratory metabolism. We noted also a significant/high significant increase in all studied biomarkers following treatment with a dose-response manner