This study evaluated a new herbal gel preparation containing extract from leaves of Ocimum Sanctum (OS) for its topical anti-inflammatory activity against carrageenan induced edema and anti-nociceptive effect. Gelling agent used in this study was 1% w/w concentration of carbopol- 940. The studies were conducted on wistar rats of either sex (160-180 g). Change in oedema volume of the rat hind paw was measured. From the study we concluded that combination of Ocimum Sanctum (OS) potentiated the anti-inflammatory and anti-nociceptive effect topically.