The anti-inflammatory activity of ethanolic extract of Dalbergia sissoo leaves , pods and bark was studied in a model of inflammation using a right hind paw edema method in Albino Wistar rats. One percent carrageenan in 0.5% sodium carboxymethyl cellulose (CMC) was administered through the sub-plantar region of the right hind paw of the animals. CMC was used as a suspending agent because it does not produce evident changes in activity response. Phytochemical investigation of leaves, pods and bark extract showed that it contained carbohydrates, proteins, amino acids, tannins and flavonoids. After oral administration of ethanolic extract at different doses (300, 500 and 1000 mg/kg), inhibition of right hind paw - edema was observed at 30, 60, and 120 min time intervals. The anti-inflammatory effects of the extract were compared with a standard dose of Indomethacin (10 mg/kg). In anti inflammatory studies, the extract was found to be safe up to 3000 mg/kg. In the Albino Wistar rats. The biological effects increased with increasing doses. The ethanolic extract of Dalbergia sissoo bark (DSEB) at 1000 mg/kg showed the most potent anti-inflammatory activity compared to the other groups (300 and 500 mg/kg) throughout the observation period.
