Hyperlipidemia a well known risk factor for cardiovascular disease, especially atherosclerotic coronary artery disease is one of the major cause of premature death globally. Cholesterol feeding has been often used to elevate serum or tissue cholesterol levels to assess hypercholesterolemia-related metabolic disturbances in different animal models. Hyperlipidemia was induced in rats by giving high cholesterol diet for seven days in standard rat chow diet. High cholesterol fed diet rats exhibited significant increase in total serum cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, atherogenic index and lipid per-oxidation and significant decrease in high density lipoprotein. The CCl4-induced hepatotoxicity model is extensively used to evaluate the hepatoprotective effects of drugs and extracts. In this study we diagnosed the different liver function parameter like, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLC) in serum by using kits. Also other diagnosed parameters such as low density lipoprotein (LDLC), atherogenic index, very low density lipoprotein (VLDL-C), HDL-C ratio and lipid per-oxidation (LPO). From obtained result it was observed that keeping the animal on atherogenic diet model (AD) significantly increased the TC, TG, LDL-C level in serum as compared to rats on normal diet. When AD was co-administered with curcumin and rosuvastatin in combination, the elevated levels of TC, TG and LDL-C and LPO condition has shown considerable decline. It was noted that TC, TG and LDL-C lowering activity of curcumin (300mg/kg) and rosuvastatin in combination was more significant as compared to curcumin and simvastatin.
