Synthetic compounds are encompassing the major therapeutic classes of drugs which resemblance to the natural or existing therapeutically active compounds. Herewith four synthetic compounds i.e. 2-bromopropylamine hydrobromide, 3-bromopropyl ammonium bromide, ortho-amino aniline and benzimidazole-2-thiol were subjected for analgesic, antipyretic, hypoglycemic and CNS depressant activity in mice and rat model following standard protocol. Among the four supplied synthetic compounds, benzimidazole-2-thiol and 3-bromopropyl ammonium bromide at a dose of 50 mg/kg body wt revealed significant analgesic activity with 37.85% and 42.85% inhibition of writhing (P value < 0.001 in both cases). None of the test samples showed antipyretic activity in rat model at a dose of 50 mg/kg body wt in comparable with standard antipyretic drug Paracetamol. On the other hand benzimidazole- 2-thiol reduced blood glucose level with respect to standard drug Glibenclamide having P value 0.00082 and 3- bromopropyl ammonium bromide lengthened the Na-phenobarbitone induced sleeping time having the P value 0.0009 which was statistically significant.
