The objective of this study was to investigate the analgesic and anti-inflammatory activity of some synthesized 2- substituted acetamido-5-aryl-1,3,4-thiadiazoles (sixteen compounds). Analgesic activity was determined by using hot wire analgesiometer. The in-vivo anti-inflammatory effects of the thiadiazole compounds were studied in a carageenan induced rat paw edema model. None of the compounds showed any analgesic activity. Some of the compounds showed moderate activity. Results indicate that substitution in the aryl group result in lessening or loss of activity. Keywords: 2,
