The Sphaeranthus indicus has been widely used for its reported biological activity in indigenous system of medicine. The present investigation was carried out to found the analgesic effect of ethanolic extract of Sphaeranthus indicus in experimental animal models of pain. The analgesic activity was evaluated by acetic acid induced writhing method in albino mice and by tail flick latency method in albino rats respectively. The percentage protection against writhing showed by ethanolic extract of SI in doses of 100, 200 and 400 mg/kg was 14.22, 36.90 and 62.20 respectively. In the tail flick model, the ethanolic extract of SI in the above doses increased the pain threshold significantly after 30 min, 1, 2 and 4 h of administration. The ethanolic extract Sphaeranthus indicus in different doses (100,200, and 400mg/kg, p.o) exhibited dose dependent and significant analgesic activity in both models of pain.
