The present study was designed to evaluate the analgesic, anti-inflammatory and antimicrobial activities of ethanolic extract of fruits of Solanum nigrum plant belonging to Solanaceae family. The anti-inflammatory activity of the extract was evaluated by using Carrageenan-induced rat paw edema while analgesic activity of the extract was evaluated for its central and peripheral pharmacological actions by using Eddy’s hot plate and acetic acid induced writhing respectively. The study was carried out using doses of 100, 250 & 500 mg/kg orally. The extract showed significant analgesic and antiinflammatory activity at the dose of 500 mg/kg (P<0.01) as compare to standard drug Diclofenac sodium (50 mg/kg). The plant extract significantly inhibited the S. aureus and B. sublitis (Gram +ve) at all the tested concentrations (100, 75, 50 and 25mg/ml) as compare to standard drug Ciprofloxacin (20 μg/ml) whereas the extract failed to show inhibitory effect against E. coli and P. aeruginosa (Gram –ve) at a concentration of 25mg/ml. The extract also showed significant inhibitory effect against C. albicans at all concentrations except at 25mg/ml as compare to standard drug Amphotericin B (100μg/ml).
