The effect of high and extra amount of methionine (%1.2 of total weight of nutrition has been considered on rabbits. 30 rabbits were divided into 2 groups of control (10) and attendance (20). The control were given nutrition without methionine and attendances were given nutrition with high and additional methionine. Taking blood was done once every 10 days. Totally during 10 step it has been done. The samples were tested for anemia. It has been continued for 3 month. The result showed that high and additional amount of methionine with the increase of the amount of homocystein of plasma leads to the damage of tissue. Also it causes mild anemia.