An attempt has been made to explore and enumerate the potential ethno-medicinal plants used by the people of Lakhimpur district, Assam. The survey was conducted in some remote areas of the district and a total of 58 medicinal plants comprising of 39 families were recorded. Different parts of these plants are used by the local inhabitants for the cure of some common ailments occurring in the areas. The data includes the list of such medicinal plants along with their local names, families, parts used, the method of treatment and the disease cured