Esomeprazole magnesium trihydrate tablets were formulated by directly compression and enteric coated with Acryl EZE for gastric protection of drug. The rheological characteristics indicated that the powder beds were freely flowable and easily compressible. The Compressional parameters after enteric coating were found to be uniform and consistent. The hardness (Kg/cm2) was found in the range of 4.133±0.321 to 4.833±0.153 with minimum friability. The enteric coated core 1 to 6 tablets not disintegrated in 0.1N HCl and the same when continued with phosphate buffer of pH 7.4 the tablets disintegrated within 96.49±0.042 sec. The drug content in all core formulations was found to be uniform and consistent. Accuracy and precision studies indicated drug content uniformity in tablet formulations. The acid uptake studies showed less than 5% acid uptake for all tablets indicated that the drug can be successfully delivered to proximal part of small intestine and could be protected from degradation in gastric environment by acryl EZE enteric coating. In the In vitro drug release studies there is no drug release or loss during gastric phase for first 2 h due to enteric coating. Later the study showed that tablets with lactose DC released higher than mannitol probably owing to its hydrophilicity and due to swelling of the super disintegrant. From the above findings it can conclude that an enteric coated Esomeprazole magnesium trihydrate tablet dosage form could be developed to deliver the drug in to proximal small intestine for more bio availability and to treat peptic ulcer.
