Solid dispersion technique is used to enhance the solubility. Glimepiride is one of the third generation sulfonylurea used for treatment of type 2 diabetes. The objective of the research project is to enhance of the solubility of Glimepiride by using solid dispersion technique. Glimepride with poloxamer 188 different ratios were prepared by spray drying method. The physicochemical properties of the products and drug-polymer interactions were characterized by Scanning Electron Microscopy, Particle Size Analysis, and Fourier transform infrared spectroscopy, Determination of drug content etc. Glimepride was found amorphously dispersed in solid dispersion systems with the drug to polymer weight ratio of 1:6. The techniques evaluated in this work resulted in improved dissolution of Glimepride. The fast dissolving tablet was prepared by using Avicel 102 as super disintegrates. The rapid disintegration and maximum drug release (97-99%) obtained in 30 min. From these results it is concluded that solubility of Glimepiride is increased by preparing solid dispersion and rapid bioavailability is observed by preparing fast dissolving tablet tablets.
