Der Pharmacia Lettre
Abstract
Author(s): Sheo Datta Maurya
The aim of the present study was to investigate the potential of ethosomal formulations for
transdermal delivery of indinavir sulphate from ethosomes. All the system were characterized for
vesicle morphology, particle size and entrapment efficiency by Scanning Electron Microscopy ,
Transmission Electron Microscopy, Differential light scattering, centrifugation, elasticity and
turbidity respectively. The effect of different formulation variable on skin permeation of
Indinavir Sulphate was studied via synthetic semipermeable membrane or skin of new born mice
by using diffusion cell. The selected system were incorporated into Carbopol934P gel and
evaluated for both drug permeation and mice skin deposition. The optimized ethosomal
formulation showed transdermal flux 25.01Ã?â??Ã?±0.34 Ã?ŽÃ?¼g/cm2/hr across rat skin as compared to
2.98Ã?â??Ã?±0.21Ã?ŽÃ?¼g/cm2/hr for plane drug solution, 4.28Ã?â??Ã?±0.54 Ã?ŽÃ?¼g/cm2/hr for hydroethanolic solution
and 9.7Ã?â??Ã?±0/21 Ã?ŽÃ?¼g/cm2/hr for classical liposomes. The obtained flux was nearly 7.5 and 12.04
times higher than conventional liposomal formulation bearing indinavir sulphate and plain drug
solution Finally it was concluded from the study that, ethosomes can increase the transdermal
flux, prolong the release and present an attractive route for sustained delivery of Indinavir
Sulphate.
