Disintegrating agents are substances routinely included in tablet formulations and in some hard shell capsule formulations to promote moisture penetration and dispersion of the matrix of the dosage form in dissolution fluids. An oral solid dosage form should ideally disperse into the primary particles from which it was prepared.Tablets and capsules which need rapid disintegration, the inclusion of the right disintegrant is a prerequisite for optimal bioavailability. Superdisintegrants are used to improve the efficacy of solid dosage forms. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate.Disintegrants are substances or mixture of substances added the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1 10 % by weight relative to the total weight of the dosage unit. Examples of Superdisintegrants are crosscarmelose, crosspovidone, sodium starch glycolate which represent example of a crosslinked cellulose, crosslinked polymer and a crosslinked starch respectively. With the increase demand of novel drug delivery, the fast dissolving/ disintegrating drug delivery system has become one of the mile stone of present investigations. The development of fast dissolving or disintegrating tablets provides an opportunity to take an account of tablet disintegrants. The disintegrants have the major function to appose the efficiency of the tablet binder and the physical forces that act under compression to form the tablet. The stronger the binder, the more effective must be the disintegrating agents in order for the tablet to release its medication. The present study comprises the various kinds of disintegrants and superdisintegrant, which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance.
