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Efficiency of dietary fish oil for regulation of hyperlipidemia and hyperglycemia in diabetic rats | Abstract
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Annals of Biological Research

Abstract

Efficiency of dietary fish oil for regulation of hyperlipidemia and hyperglycemia in diabetic rats

Author(s): Mahdi Hamadani, and Maryam Asadiagajari, Tohid Vahdatpour, Yadollah Bahrami, Karim Salehzadeh and Sina Vahdatpour

The efficacy of fish oil (FO) on serum biochemical parameters and performance was investigated in streptozotocin (STZ)-diabetic rats. Four weeks before the start of FO treatment, diabetes was induced in rats by a single intraperitoneal injection of streptozotocin (STZ = 60 mg/kg bodyweight). Then, male Wistar rats (n = 32) were randomly divided into 4 groups of non-diabetic (T1, control), treated non-diabetic (T2), diabetic (T3), and treated diabetic (T4). Standard rat non-purified diet was fed either alone or supplemented with an additional 2.5% fish oil. Diabetic rats had significantly increased serum levels of cholesterol, triglycerides, glucose and low density lipoprotein cholesterol (LDL-C) and decreased serum high DL-C concentration. The fish oil treatment of diabetic rats resulted in significant recovery in bodyweight, heart weight: bodyweight ratio and blood glucose levels. The administration of FO reduced cholesterol, triglyceride and LDL-C levels, and increased HDL-C levels, in the serum of diabetic rats. In conclusion, fish oil can reduce the risk of cardiovascular disease in diabetes with a significant improvement and regulation in lipid metabolism and also can moderate glucose level of diabetic rats and regulate its secretion that may be reduce of type 1 diabetes mellitus.