There are several anthelmintic classes based on chemical structure that are in use, but, during the last 20 years, it has been increasingly noted that the target parasites have become resistant, the incidence varying with geographical location and mode of use. In this study, 90 apparently healthy sheep under the same management conditions of the experiment, feces (EPG) were examined. sheeps devided to 3 groups(30=control, 30=treated with closantel 5% Damloran, 30=treated with closantel 5% Jamedat-afag) then treated sheeps received 1 mg/kg B.W closantel 5% oraly and After treatment the sheep, faecal samples from each of 3 groups were examined in days 1-7-21-28 after treatment by wet-mount and willis-methods and MC-master slid used for egg counte. Therefore Closantel 5% drugs that manufactured by drug Damloran and Jamedatafag company if used oraly by dosage1 ml/10kg B.W in sheep against Fasciola hepatica, and Haemonchus contortus, Oesophagostomum columbianum been quite effective (average percentage of drug effect = 91%) and used for control and prevention of parasitic infections in sheep is recommended.
