Crop plants are usually affected by environmental stresses. Among different possible stresses, irrigation and available nitrogen supply are two of most important stresses for the plants. Surveys of the effects of draught and phosphorous bio-fertilizer on yield and element of yield of safflower were conducted through a farm test in form of split plot and in block frame. The experiment was conducted randomly with four replications in 2012. The surveys were on three levels of draught stresses (control, no irrigation during stem development, and no irrigation during flowering) and four level of phosphorous bio-fertilizer (control, Phosphor 25%, Phosphor 50%, Bio-Phosphate). The traits under consideration were yield, weight 1000 grains, total number of seeds in tray, total number of heads, and length of plant. The results showed significant differences of traits between draught stress samples and nitrogen bio-fertilizer stress samples. However, no significant difference was found regarding reciprocal effects. Results concerning agricultural traits showed that no irrigation after stem development negatively affected the sample. The best grain yield was obtained for ordinary irrigation sample (control group) and phosphorous bio-fertilizer of 25% and 50% with yield of 4949 and 5029kg/ha.