Anaesthetics currently used, such as ketamine and Telitamine may differently affect a number of physiological parameters include glucose, urea, creatinine, alkaline phosphatase, AST, and ALT.and its effects have been widely studied in particular the influence of anesthetic molecules on plasma biochemical parameters in a variety of animal species (rabbits, rats, mouses ...).The aim of our study was to compare the effect of three anesthetic protocols on certain plasma biochemical parameters order to have a protocol that has the finest effects. We conducted on 35 rats ( Rattus norvegicus) divided into seven groups of 05 different individuals anesthesia under standardized conditions .Three protocols were tested, ketamine alone (K), ketamine + Acepromazine (K-A) , Tiletamine + Zolazepam (Z) . It seemed possible that these protocols do not generate significant changes in blood biochemical parameters of rats used in this study (GLUCOSE, UREA, CREATININE, AST, ALT, ALP) except that urea was observed an increase in values whose the levy is made in day 0 (D0) and 120 minutes after administration , which guide us to a suspicion of possible effect of general anesthesia regardless of the protocol on the renal function in laboratory rats . Given the importance of variations observed results, it is difficult to exclude any influence of the injection of ketamine - acepromazine , ketamine alone or tiletamine - zolazepam on these variations. We must remain vigilant in the interpretation of the analyte during sedation in these protocols.
