Purpose: This study aimed to determine the effect of energy therapy on saphenous vein incision pain after coronary artery bypass grafting [CABG]. Methods: Forty patients after CABG were randomly assigned to Reiki and Sham Reiki groups. The intensity and sensory as well as affective qualities of pain were measured before and after the interventions. The patients underwent Reiki healing energy and sham Reiki for 9 minutes. The short and modified version of the McGill pain questionnaire and the Visual Analog Scale was used for pain measurement. Results: There was a significant difference between the Reiki and sham Reiki groups in the mean scores of pain sensory quality in the legs. However, no statistically significant difference was found between the two groups in the mean scores of pains severity and affective quality of pain in the legs [P>0.05]. Conclusion: Reiki could be used as a simple and cost-effective nursing intervention for managing sensory dimension of pain quality in the patients’ after CABG.